Protein structure modelling (IN-PERSON) New
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Determining the 3 dimensional (3D) structure of a protein from its amino sequence is vital for understanding its core biological functions. This can be done using experimental approaches, which are the standard for validating high-resolution and accurate structures. However, these methods can be costly, time-consuming and technically difficult to achieve for certain proteins. To complement these approaches, computational methods can be used, which increase the speed of prediction, can be scaled to higher throughput and are much cheaper to run.
This course covers how to computationally predict the 3D structure of proteins from their amino acid sequences. We will focus on AlphaFold, a software that has revolutionised this process due to its outstanding (near-experimental) prediction accuracy. Other key aspects will be covered such as retrieving structural information from public databases, evaluating the quality of the predicted models, model visualisation with PyMOL, multimer predictions, prediction of ligand binding sites and docking. After this course you should be able to produce 3D predictions of your proteins, while critically evaluating the output of the methods covered in the course.
If you do not have a University of Cambridge Raven account please book or register your interest here.
- ♿ The training room is located on the first floor and there is currently no wheelchair or level access.
- Our courses are only free for registered University of Cambridge students. All other participants will be charged according to our charging policy.
- Attendance will be taken on all courses and a charge is applied for non-attendance. After you have booked a place, if you are unable to attend any of the live sessions, please email the Bioinfo Team.
- Further details regarding eligibility criteria are available here.
- Guidance on visiting Cambridge and finding accommodation is available here.
- Everyone is welcome to attend the courses, please review the relevant policies.
Understanding of the basics of protein structure is expected.
Bioinformatics, Data visualisation, Protein structure analysis
Presentations, demonstrations and practicals
Participants can make use of the computers in the training room .
- Free for registered University of Cambridge students
- £ 60/day for all University of Cambridge staff, including postdocs, and participants from Affiliated Institutions. Please note that these charges are recovered by us at the Institutional level
- It remains the participant's responsibility to acquire prior approval from the relevant group leader, line manager or budget holder to attend the course. It is requested that people booking only do so with the agreement of the relevant party as costs will be charged back to your Lab Head or Group Supervisor.
- £ 60/day for all other academic participants from external Institutions and charitable organizations. These charges must be paid at registration
- £ 120/day for all Industry participants. These charges must be paid at registration
- Further details regarding the charging policy are available here
2 days
Once per year
Events available