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Instructor-led course

Provided by: Bioinformatics

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Protein Structure Analysis


This course covers analytical approaches for the interpretation of biomacromolecular structures including how to find information about the structure and function of your protein sequence using CATH, principles of modern state-of-the-art protein modelling with Phyre2 and methods for predicting the effects of mutations on protein structure and function using the SAAP family of tools. In addition, we will look at mapping genetic variants onto structures as well as visualisation and basic analysis of protein structures.

The training room is located on the first floor and there is currently no wheelchair or level access available to this level.

Please note that if you are not eligible for a University of Cambridge Raven account you will need to book or register your interest by linking here.

Target audience
  • Graduate students, Postdocs and Staff members from the University of Cambridge, Affiliated Institutions and other external Institutions or individuals
  • Please be aware that these courses are only free for registered University of Cambridge students. All other participants will be charged a registration fee in some form. Registration fees and further details regarding the charging policy are available here.
  • Further details regarding eligibility criteria are available here

Understanding of the basics of protein structure is expected.

Topics covered

Bioinformatics, Data visualisation, Protein structure analysis


After this course you should be able to:

  • Scan a protein sequence against CATH and interpret the significance and biological meaning of results
  • Create your own protein models and analyse their features and assess their reliability
  • Use mutation prediction methods and evaluate their performance.

During this course you will learn about:

  • How CATH provides information on protein sequence, structure and function
  • How protein modelling works, how to model your own proteins and when to trust the results
  • An overview of approaches to mutation effect prediction and their performance and limitations

Presentations, demonstrations and practicals


Day 1 Topics
10:00 – 13:00 Using CATH to find information about the structure and function of your protein sequence
13:00-14:00 Lunch (not provided)
14:00 – 16:30 Impact of genetic variation on protein structure and function
Day 2
10:00 – 12:30 Visualisation and basic analysis of protein structures
12:30 - 13:30 Lunch (not provided)
13:30 – 14:30 Mapping genetic variants onto structures
14:30 – 16:30 Homology modelling
Registration fees
  • Free for registered University of Cambridge students
  • £ 50/day for all University of Cambridge staff, including postdocs, and participants from Affiliated Institutions. Please note that these charges are recovered by us at the Institutional level
  • It remains the participant's responsibility to acquire prior approval from the relevant group leader, line manager or budget holder to attend the course. It is requested that people booking only do so with the agreement of the relevant party as costs will be charged back to your Lab Head or Group Supervisor.
  • £ 50/day for all other academic participants from external Institutions and charitable organizations. These charges must be paid at registration
  • £ 100/day for all Industry participants. These charges must be paid at registration
  • Further details regarding the charging policy are available here



A number of times per year

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Specialized Training

Events available