BIO3 Multidomain Biosynthetic Enzymes: PKS & NRPS

Polyketides, made by polyketide synthases (PKS), and non-ribosomal peptides, made by non-ribosomal peptide synthases (NRPS) are futher large classes of natural products containing very important medicinal compounds, including antibiotics erthyromycin (PKS), penicillins and vancomycin (NRPS). Unlike the alkaloids and terpenes, which are made by a succession of steps catalysed by monofunctional enzymes, polyketides and non-ribosomal peptides are generally made by huge multifunctional proteins, to which the starting material is tethered at the start of the process and then extended and modified by a series of domains in the protein, before finally being released at the end of the chain. This lecture will look at the mechanisms involved and the organisation of these "molecular production lines".

Number of sessions: 1