All-provider course timetable

This course will cover safe storage and use of cryogens, safe use and stores of compressed gas, and aspects of oxygen depletion with respect to the above.

One session covering the HDAS databases, targeted at allied health professionals. Learn how to get the best out of your literature searches.

DRUG DISCOVERY (DD) (I)

(DD3) Targeted Anti-Cancer Therapeutics (2L)

The targeted delivery of effector molecules into diseased tissues has emerged as a promising strategy for the treatment of cancer and other serious conditions. Linking a therapeutic effector (e.g. cytotoxics, proinflammatory cytokines or radionuclides) to a ligand specific to a marker of disease results in preferential accumulation of the effector molecule at the target tissue. This offers the double benefit of increased effective concentrations at the intended site of action and low concentrations in healthy tissues, thus reducing side effects. In the course of these two lectures we will discuss strategies for the discovery of selective ligands against markers of disease, conjugation chemistry in the context of drug-delivery strategies, and examples of recently approved FDA drug conjugates for the treatment of cancer.

The overall aim of these one-to-one sessions is to help you identify the skills you would like to develop to be more effective both during and after your PhD. Topics covered include: evaluating your current skill levels; identifying the areas you wish to focus on to create a tailored development plan.

The overall aim of these one-to-one sessions is to help you identify the skills you would like to develop to be more effective both during and after your PhD. Topics covered include: evaluating your current skill levels; identifying the areas you wish to focus on to create a tailored development plan.

The overall aim of these one-to-one sessions is to help you identify the skills you would like to develop to be more effective both during and after your PhD. Topics covered include: evaluating your current skill levels; identifying the areas you wish to focus on to create a tailored development plan.

The overall aim of these one-to-one sessions is to help you identify the skills you would like to develop to be more effective both during and after your PhD. Topics covered include: evaluating your current skill levels; identifying the areas you wish to focus on to create a tailored development plan.

To provide an opportunity for someone from elsewhere in the Finance Division to spend half a day with the AP Team/Cashier to get an overview and appreciation of what they do.

Jalview hands-on training course is for anyone who works with sequence data and multiple sequence alignments from proteins, RNA and DNA.

Jalview is free software for protein and nucleic acid sequence alignment generation, visualisation and analysis. It includes sophisticated editing options and provides a range of analysis tools to investigate the structure and function of macromolecules through a multiple window interface. For example, Jalview supports 8 popular methods for multiple sequence alignment, prediction of protein secondary structure by JPred and disorder prediction by four methods. Jalview also has options to generate phylogenetic trees, and assess consensus and conservation across sequence families. Sequences, alignments and additional annotation can be accessed directly from public databases and journal-quality figures generated for publication.

The course involves of a mixture of talks and hands-on exercises.

Day 1 is an introduction to protein multiple sequence alignment editing and analysis with Jalview.

Day 2 focuses on using Jalview for RNA sequence analysis, and also integrating cDNA and protein analysis and covers more advanced applications after lunch.

Day 3 concentrates on protein secondary structure prediction with JPred version 4 as well as protein sub-family analysis to identify functionally important residues.

There will be opportunities for attendees to get advice on analysis of their own sequence families.

Further information, including some training videos, is also available.

Please note that if you are not eligible for a University of Cambridge Raven account you will need to book by linking here.

Before undertaking any piece of primary research it’s important to be aware of as much of the existing literature as possible. A systematic literature review can also be a research end in itself. And it’s not something to be taken lightly. But how can you be sure you’re being as rigorous as necessary? How can you manage the references you find, document the process, and also know when to stop searching?

If you need to do a systematic literature review, and you’re not able to make sense of the search strategy behind this paper then this course is for you. Please bring along details of your own topic so that the session can be tailored to address your specific needs.

CHARACTERISATION TECHNIQUES (CT)

(CT6) Understanding NMR Spectroscopy (11L)

By now you will be familiar with the use of NMR as a qualitative tool for structure determination, but little has been said so far about what NMR spectroscopy actually is and how it works. One of the beauties of NMR is that you can use it every day to help in identifying chemical structures without ever having to worry about what is actually going on in the experiment. However, there comes a time when either our curiosity, or our need to understand more deeply what we are doing, brings us to the point where we really want to know what NMR is. This is where this course fits in.

The course starts out by considering the basic NMR experiment which, it turns out, is performed in rather a different way to virtually all other kinds of spectroscopy. Rather than looking for the absorption of radiation by the spins, we excite the spins with a short burst of radiation and then detect the ringing signal which is induced. The Fourier transform of this ringing signal is the familiar spectrum. In order to understand this most basic experiment we will have to develop the vector model, which is a precise semi-classical way of understanding the behaviour of the spins. Once we have the vector model we can begin to explore other experiments which involving pulses, including the famous spin echo experiment, which is the basis for many further developments.

Useful though the vector model is, it is not able to describe the behaviour of coupled spins, and in particular the important phenomena of coherence transfer and multiple quantum coherence. To deal with these effects we need the quantum mechanical approach offered by the product operator method. We will not concern ourselves too much with where this theory comes from, but will find that it can be used in a simple and intuitive way to explain all of the important phenomena in modern NMR. In particular, we will be able to understand how two-dimensional experiments, with such delightful names as COSY, DQF-COSY and HMQC work. It is these experiment which have so revolutionized the application of NMR over the past twenty years.

Time permitting, we will also look at relaxation in NMR spectroscopy. In contrast to most other kinds of spectroscopy, the excited states generated in pulsed NMR are very long-lived, and this means that it is relatively easy to study the way in which these states return to equilibrium – which is what relaxation is. The rate of relaxation gives important insight into molecular motion, and relaxation is also responsible for the nuclear Overhauser effect (NOE) which is an exceptionally important tool in structure determination by NMR.

Recommended books:

James Keeler Understanding NMR Spectroscopy , Wiley 2005 (The course will largely be based on this text) Hore, P. J., Nuclear Magnetic Resonance , OUP 1995.

The writing workshops will cover a mixture of structure, accuracy and style in academic English writing.

To provide an opportunity for someone from elsewhere in Finance Division to spend half a day in the Financial Reporting Team to get an overview and appreciation of what they do.

Would you like to learn exercises that will reduce vocal strain, improve vocal range, variety, clarity and pronunciation and gain and hold the attention of an audience? Would you like to make a positive initial impact and keep control of difficult situations? In this individualised and confidential one-hour session you will determine the objectives and work on exercises to address your specific interests.

Moodle as the Virtual Learning Environment will be supporting teaching and learning at the University.

This is an advanced course for those who administer courses in Moodle and would like to use the Feedback activity to survey their course members.

USS Pension Presentation.

Would you like to learn exercises that will reduce vocal strain, improve vocal range, variety, clarity and pronunciation and gain and hold the attention of an audience? Would you like to make a positive initial impact and keep control of difficult situations? In this individualised and confidential one-hour session you will determine the objectives and work on exercises to address your specific interests.

Would you like to learn exercises that will reduce vocal strain, improve vocal range, variety, clarity and pronunciation and gain and hold the attention of an audience? Would you like to make a positive initial impact and keep control of difficult situations? In this individualised and confidential one-hour session you will determine the objectives and work on exercises to address your specific interests.